While Dallas (13-2) moved a step closer to clinching home-field advantage throughout the playoffs, the Cowboys were dealing with another injury to a key offensive player.
Last week it was Romo, who bruised his right thumb and was ineffective in a loss to Philadelphia. Now it's Owens, who left in the second quarter after his left leg got caught underneath him after a catch.
The Cowboys made it 14-0 a play after Owens left, but failed to score another touchdown.
The team said at halftime that he would miss the rest of the game.
Owens' leg got caught underneath him when he was tackled by Jon Beason on a 4-yard catch in the second quarter. After limping around on the sideline for several minutes, Owens walked to the locker room.
A television camera later caught Owens walking near the locker room without a shoe on his left foot, accompanied by a trainer and agent Drew Rosenhaus.
Owens had five catches for 48 yards, including a 10-yard touchdown catch, before he was injured. The TD was Owens' team record 15th of the season.